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AFP1 results from o-demethylation while the AFB1 epoxide is formed by epoxidation at the 2,3 double bond Aflatoxicol is the only metabolite of AFB1 produced by a soluble cytoplasmic reductase enzyme system [46]

Because this process happens at a cellular level over several weeks or months, some protocols suggest higher doses to ensure enough glutathione reaches the skin cells

PloS One (2016) 11(11):e0165125

A striking and still unresolved observation is that the most vulnerable neuronal populations differ markedly across disorders, affecting distinct brain regions such as the hippocampus in AD, the substantia nigra in PD, or the motor cortex and spinal cord in ALS