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Histone modifications occur at the N-terminal tails of histones, which can alter chromatin structure directly by affecting the local charge of the histone protein and thereby the histone-DNA interactions or by recruiting effector proteins which subsequently change the chromatin conformation 30

When considering that the frequency of both polymorphisms is high (almost 50% for bupropion (genotype AA) and 70% for varenicline (genotypes CT or TT)), it is possible that participants who were willing to undergo blood sampling for genetic purposes were part of the subgroup most successful at smoking cessation treatment

However, some studies that tracked populations of young people over time found that increased e-cigarette use was associated with lower smoking rates across populations. Some also found that as youth vaping decreased, subsequent youth smoking went up, she said

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