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Reduced SOD2 activity also increases susceptibility to oxidative stress

Now, there are a bunch of theories as to why the pineal regresses with age

Some research from Germany has shown that an even higher threshold (over 500 pg/mL) is necessary in early-to-mid pregnancy to maintain vitamin B12 levels throughout pregnancy, lactation, and to support an infants vitamin B12 status (via breast milk) through 6 months of age