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It is produced naturally in our bodies, primarily in the liver, and is involved in numerous physiological processes

Investigators must ensure that all samples (subjects and controls) are collected and processed as uniformly as possible given that most platforms can quite easily reveal signs of improper handling (e.g., hemolysis, anticoagulation additives, improper solvent use, etc.), nutritional supplementation, environmental exposures, and fasting status

e and f , Levels of guanidoacetate m + 2 in liver (e) at 45 min and urine (f) at 2 h in Het or KO mice