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Moreover, in the hypothyroid animals, many of the mast cells showed partial or complete degranulation, which was in contrast to the non-activated mast cells in the animals with normal thyroid function.[ref] Other animal studies show that hypothyroidism increases mast cell infiltration into the liver and mast cell levels in the bone marrow

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Clinical trials are ongoing, and Novo Nordisk has indicated plans to file for approval

Rare adverse events that might emerge in large systematic studies could remain invisible in informal self-experimentation