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For the Spirulina effect on liver, clinical studies have been conducted to determine the hepatoprotective effects on patients with liver fibrosis and chronic liver disease
Oxidative stress and mitochondrial damage are inextricably linked to RA development, and our focus was on the mitochondrial regulation of metabolism affecting the disease process of RA

Sci Rep 6:33072 Stroes ES, Thompson PD, Corsini A, Vladutiu GD, Raal FJ, Ray KK, Roden M, Stein E, Tokgzolu L, Nordestgaard BG, Bruckert E, de Backer G, Krauss RM, Laufs U, Santos RD, Hegele RA, Hovingh GK, Leiter LA, Mach F, Mrz W, Newman CB, Wiklund O, Jacobson TA, Catapano AL, Chapman MJ, Ginsberg HN, European Atherosclerosis Society Consensus Panel, Stroes E, Thompson PD, Corsini A, Vladutiu GD, Raal FJ, Ray KK, Roden M, Stein E, Tokgzolu L, Nordestgaard BG, Bruckert E, Krauss RM, Laufs U, Santos RD, Mrz W, Newman CB, John Chapman M, Ginsberg HN, John Chapman M, Ginsberg HN, de Backer G, Catapano AL, Hegele RA, Kees Hovingh G, Jacobson TA, Leiter L, Mach F, Wiklund O (2015) Statin-associated muscle symptoms: impact on statin therapyEuropean Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management