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Yes, Prozac (Fluoxetine) can potentially cause weight gain, although it is not as commonly associated with weight gain as some other antidepressants

there is, however, sufficient evidence that consumption of high-calorie, energy-dense foods and beverages and lack of physical activity play a significant role in obesity (127)

Nicotine, commonly found in cigarettes, e-cigarettes, and some tobacco products, is a powerful chemical, depending on the dose, that affects the central nervous system (CNS) and the peripheral nervous system (PNS)

When Clooney directed Good Night, and Good Luck, he faced criticism from anti-smoking groups who took issue with the films frequent depictions of cigarette use