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This gene modulation capability extends to shifting gene expression in COPD lungs from a destructive state to one of healthy remodeling, showcasing its broad therapeutic potential 13

Once formed, superoxide radicals are dismutated in mitochondria by manganese superoxide dismutase (MnSOD) to hydrogen peroxide (H 2 O 2 ) and molecular oxygen (O 2 ), or react with endogenous nitric oxide (NO) to form peroxynitrite (ONOO ) [50]