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The Rebound Effect Perhaps the most frustrating long-term impact: what happens when treatment ends

This is particularly relevant for significant injuries, post-surgical recovery, chronic conditions that have resisted single-agent approaches, or patients dealing with both musculoskeletal and inflammatory components simultaneously

Campanholle G, Ligresti G, Gharib SA, Duffield JS

For example, retatrutide , a medication currently in clinical trials, is a triple agonist that targets GLP-1, GIP, and glucagon receptorsan approach designed to amplify fat-loss and metabolic effects