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Intramuscular and intravenous delivery bypasses the gastrointestinal tract, achieving significantly higher bioavailability than oral supplementation, making injectable micronutrients a clinically effective option for patients with confirmed or suspected deficiency, malabsorption conditions, or chronic illness

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This phenomenon is marked by an increasing accumulation of macrophages and lymphocytes in the renal interstitium, which may significantly contribute to either the onset or the exacerbation of renal function decline over time