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The liver is the largest organ providing immune and metabolic functions, and its ectopic lipid accumulation has been widely recognized as one of the factors potentially influencing PCOS metabolic syndrome, despite ongoing debates about the causal relationship between hepatic fat deposition and hepatic insulin resistance in recent years, the correlation between the two is undeniable (Li M

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Furthermore, the research indicated that the enhanced ferroptosis observed in SLC39A14 knockdown cells is linked to alterations in the cGMP-PKG signaling pathway