acetyl l carnitine 功效

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doi: 10.1194/jlr.D082370 165 O'NeillLAHardieDG

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Reactions of myeloperoxidase-derived oxidants with biological substrates : gaining chemical insight into human inflammatory diseases

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Thus, since several mutations affecting the functional domains of p62 have been identified in patients with ALS and frontotemporal dementia, it has been demonstrated that p62 variants exhibit reduced KEAP1-binding, preventing NRF2 from entering the nucleus and promoting protective genes, and predisposing the cell death upon exposure to ROS [250, 251]