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For Lebers optic atrophy or smokers blindness, the usual dose starts at 1000mcg, given daily for 2 weeks, followed by twice weekly

Genotyping studies looking at single nucleotide polymorphisms (SNPs) have also revealed that specific variants of the ABCC2 gene were prognostic of tumor recurrence during tamoxifen monotherapy 66

Behavioral assessments (open-field, self-grooming, social interactions) were followed by biochemical and molecular analyses in the cerebellum, where oxidative stress markers (MDA, GSH, SOD, CAT, and GPx) were quantified spectrophotometrically, and Nrf2, Bax, Bcl-2, and Caspase-3 mRNA levels were measured by q RT-PCR

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