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Such a condition demands larger-scale clinical or randomized control trials worldwide, which need to include quantification of brain creatine and dietary measures to better understand habitual or supplemented dietary intake of creatine in response to such an intervention

Its ultimately up to the agency to decide whether to follow the recommendations

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Patients with an inherited disorder of bilirubin excretion into the canaliculus, such as Dubin-Johnson syndrome or Rotor syndrome, have hyperbilirubinemia that is more than 80% conjugated