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17 In contrast, unlocked nucleic acid (UNA) is a flexible RNA mimic that lacks chemical bonds between the ribose rings C2 and C3 atoms

Undoubtedly, understanding the possible metabolic mechanism of drugs in vivo and evaluating the procedure with relevant models is of great significance for screening potential clinical drugs

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For example, accumulation of ceramides in the mitochondria of skeletal muscle cells showed loss of the mitochondrial respiratory chain components, resulting in mitochondrial dysfunction and insulin resistance (Zigdon et al., 2013)