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Cycling with breaks of 2-4 weeks between protocols may help maintain response

Liu Y, Yan Z, Zhang L, Deng Z, Yuan J, Zhang S, Chen and Guo R 2019 Food up-take and reproduction performance of Daphnia magna under the exposure of Bisphenols

It has shown efficacy in animal models of inflammatory bowel disease (IBD), gastric ulcers, and "leaky gut." Systemic anti-inflammatory effects: It appears to dampen inflammatory cascades without the immune-suppressing risks associated with corticosteroids

Those antibodies could make future doses less effective, increase the risk of future reactions, or, in some therapeutic proteins, interfere with related natural proteins in the body