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3.3 Reverse regulation of oral microbiota by gut microbiota 3.3.1 Reverse regulation of oral microbiota by gut microbiota via the immune system and endocrine system Systemic immune responses modulated by the gut microbiota further influence the local oral immune environment through immune cell migration and signaling pathways, thereby indirectly regulating the composition and function of the oral microbiota (An et al., 2025)