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In del[13q]CLL cells, the microRNA (miR) cluster miR-15a/miR-16-1 is deleted, leading to the loss of its tumor suppression function and overexpression of the antiapoptotic proteins B-cell lymphoma-2 (BCL-2) and myeloid cell leukemia-1 (MCL-1)

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We are going to discuss the association between NF-B and HGF/c-Met and EpCAM in the following sections