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Description

The fasted administration requirement exists because insulin interferes with AOD 9604 lipolytic activity

In borderline cases, methylmalonic acid or homocysteine levels may be tested

Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss