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A subsequent trial comparing reduced glutathione to oxidized glutathione (GSSG) over 12 weeks found that both forms produced measurable skin brightening, with improvements in melanin index, UV spots, and skin wrinkles beginning at week 4 and progressing through week 12 (Weschawalit et al., 2017)

put proper amount evenly onto the face and tap the face until full absorption

Sterile water lacks this preservative, meaning any contamination introduced during mixing will multiply unchecked