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According to Dana Hancock, a co-author of the study, "The variant that we identified is common, occurring in 44 percent of Europeans or European Americans and 77 percent of African Americans, and it exerts important effects on gene regulation in the human brain, specifically in the cerebellum (RTI International: 2017)." A variant of another gene, CHRNA5, can double ones likelihood of developing an addiction to nicotine

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They also attempted to thwart the policy through lobbying and third-party interference, and unsubstantiated claims about the effect on price, businesses and illicit trade