PMID: 24397061
SELENOF, Recombinant Deiodinase, Iodothyronine, Type II (DIO2), SELENOS, SELENON, SELENOK, SELENOM, and SELENOT are considered to be seven endoplasmic reticulum resident proteins with oxidoreductase activity and can participate in a series of processes, such as the regulation of endoplasmic reticulum redox state, endoplasmic reticulum stress and intracellular Ca 2+ homeostasis (Rathore et al., 2021
This data suggests that while lower doses (5-15g) are excellent for maintenance and mild IBS, repairing severe, pathological "leaky gut" may require transient, high-dose interventions under medical supervision to rapidly force the reassembly of tight junction proteins
Hence its popularity in skin creams, serums and lotions, all meant for topical application