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10.1038/nrendo.2016.164 41 LuY.ChenX.YinZ.ZhuS.WuD.ChenX

Toxicant channeling A hypothesis in which it is suggested that reactive sulfur-containing species generated from toxic cysteine S -conjugates are channeled from the active site of mitochondrial aspartate aminotransferase to -ketoglutarate dehydrogenase complex, thereby accounting for the remarkable sensitivity of this enzyme complex to inactivation in tissues/cells exposed to certain toxic cysteine S -conjugates

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