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182 The senescence and exhaustion of HSCs are the core reasons for the decline in hematopoietic system function, involving multiple mechanisms such as telomere attrition, oxidative stress, inflammatory disorders and epigenetic disorders, which ultimately lead to anemia, immunodeficiency, and an increased risk of hematological diseases

Dietary and lifestyle changes aimed at improving insulin sensitivity and body composition are a central pillar of an effective treatment plan

However, in the context of dysbiosis, this immune response is often exaggerated and prolonged, leading to chronic inflammation as reported [44]

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