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Rinderknecht E, Humbel RE

Neurological symptoms, such as numbness or tingling in the hands and feet, difficulty walking, and memory problems, are also symptoms

135 Our experiments in rats with Ang IV and with more selective AT 4 -ligands, LVV-H7 and AT416, did not reveal any putative AT 4 /IRAP-mediated vasodilator response neither after systemic nor after renal administration, and also not after AT 1 receptor blockade

Severe complications of a caffeine overdose are rare, but can include: A healthcare provider will diagnose a caffeine overdose with a physical exam and some tests