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PLoS ONE 11 , e0153819 (2016)

To view a copy of this licence, visit About this article Cite this article Nwankwo, N.E., David, J.C

The results are often cumulative, and regular infusions may be needed to sustain the benefits over time

NNMT plays a key role in metabolic dysfunction, and its inhibition has been shown to reverse obesity-related changes in adipose tissue. Kraus et al., Cell Metabolism How 5-Amino-1MQ Works The primary mechanism behind 5-Amino-1MQ lies in its ability to inhibit nicotinamide N-methyltransferase (NNMT) an enzyme that is often overexpressed in fat cells, cancer cells, and aging tissues