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However, an excessive production of melanin causes dermatological problems such as freckles, solar lentigo (age spots) and melasma 69 , as well as cancer 10 and postinflammatory melanoderma 11

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Aside from iron, ferroptosis can be triggered by low uptake of cysteine or glutamine via SLC7A11, an amino acid transporter specific for cysteine and glutamate, as well as the loss of GPX4 ( Recent studies have found that both cART and the HIV-1 antigen, trans-activator of transcription (Tat), alter the host ELS, upregulating ferritinophagy and iron release (Tripathi et al., 2019