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The molecular pathways by which mitochondrial derangements act as a unifying pathophysiological link between these conditions are explored in detail, with a particular focus on the oxidative stressinflammation cascade, damage to the vascularneural unit, and systemic metabolic reprogramming

In mice subjected to social defeat stress, brain lactate levels and lactylation correlate positively with neuronal activity, suggesting that lactylation contributes to neural regulation in depression and anxiety (Sun et al., 2023)

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