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HPV infection is said to be mainly transmitted via oral sex and the incidence of HPV-positive HNSCC continues to rise among population that are not vaccinated against HPV prior to its exposure

140 activated macrophages, while crucial for immune responses, can also release large quantities of inflammatory cytokines, which may have the potential to harm the host

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they can communicate information, sense danger when the cell energy levels drop, and are even involved in sending the final "death" message (apoptosis) when a cell is damaged beyond repair and needs to die