Extending the "Anagen" (growth) phase of the hair cycle
Valvular abnormalities have been reported in individuals with TN-X deficiency
Montalban-Bravo G, Benton CB, Kanagal-Shamanna R, Sasaki K, Assi R, Kadia TM, Ravandi F, Ganan-Gomez I, Cortes JE, Daver NG, Takahashi K, DiNardo CD, Jabbour EJ, Borthakur G, Pemmaraju N, Konopleva MY, Pierce SA, Bueso-Ramos CE, Kornblau SM, Patel K, Colla S, Kantarjian HM, Andreeff MA, Garcia-Manero G
Moreover, our cell-based activity assays showed that the HGF with mutations that disrupt either K1SEMA or SPHSEMA interaction no longer activated c-MET, but the HGF with mutations that disrupt either NSEMA, K2SEMA, or K3SEMA interaction still exhibited partial activity, suggesting that the K1SEMA and SPHSEMA interfaces are more critical for HGF-induced c-MET activation than any other interfaces