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That is a consistent pattern of failure to demonstrate the primary endpoint: significant fat reduction in humans

GSH-dependent glyoxalase 1 and 2 mediate the detoxification of 2-oxoaldehydes, such as methylglyoxal, which is an electrophilic by-product of glycolysis that reacts spontaneously with proteins, lipids, and nucleic acids, causing irreversible damage [139]

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P., Jr, Nichenametla, S., Neidig, W., Calcagnotto, A., Haley, J