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Description

Many are confined to a re-discussion of Nrf2 and HDAC inhibition, lacking integration with its biosynthetic origins and failing to synthesize the rapidly expanding body of evidence on novel and underappreciated mechanisms

NRF2 as a therapeutic opportunity to impact in the molecular roadmap of ALS

10.1371/journal.pone.0074860 PLoS One Summary Keywords ubiquitination, deubiquitination, transcriptional regulation, molecular clock, protein homeostasis Citation Costanzo KM, Prifti MV, Todi SV and Mohan RD (2025) The ubiquitin-proteasome system in circadian regulation