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This subjective improvement could reflect placebo effect, improved overall nutritional status from paying more attention to diet, natural adaptation to the medication over time, or actual b12 repletion if deficiency existed

10.3389/fphar.2019.00348 107 LiY.LermanL

Kobrinsky NL, Hartfield D, Horner H, et al

In this context, cocaine, diamorphine (heroin), methylenedioxymethamphetamine (MDMA/ecstasy) and tetrahydrocannabinol (THC) are designated as Substances of Abuse