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Binding of the NO to the COX can also cause intracellular signaling events, including oxygen diversion to non-respiratory substrates and ROS production with potentially destructive effects (158)

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Controlling the role of BPC 157 likely involves its particular interaction with the major systems involved in wound healing, such as the NO-system (counteracted harmful events, arising from either NO-blockade or NOS-substrate application) (Sikiric et al., 2014) and the prostaglandins system (i.e., large extent of the counteracted NSAIDs toxicity (Sikiric et al., 2013) as well as counteracted developing and already formed adjuvant arthritis in rats (Sikiric et al., 1997c))

Res Vet Sci 129:103108 Zhang H, Wang J, Lang W, Liu H, Zhang Z, Wu T, Li H, Bai L, Shi Q (2022) Albiflorin ameliorates inflammation and oxidative stress by regulating the NF-B/NLRP3 pathway in Methotrexate-induced enteritis