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34 DNA methylation mediates smoking and genotype interaction in ANPA-positive RA

The catabolism of 2-HG is catalyzed by stereospecific dehydrogenases, D-2-hydroxyglutarate dehydrogenase and L-2-hydroxyglutarate dehydrogenase

Pharmacological targeting of CHAC1-mediated processes therefore represents a rational therapeutic strategy, potentially disrupting the cycle of GSH depletion, ER stress amplification and iron-dependent peroxidation that drives neuronal loss

The progressive neurodegenerative illness amyotrophic lateral sclerosis (ALS) damages motor neurons in the brain and spinal cord, resulting in muscle weakening and atrophy (Zarei et al., 2015)