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Therefore, the balance of ROS is crucial for GSCs and ESCs to maintain their stem cell activity and differentiation capacity

Mechanism of action against RA Anti-inflammation and anti- oxidation COX-2, a key mediator in the inflammatory process, catalyzes the hydrolysis of glycerophospholipids to release arachidonic acid, which is converted to PGs, including prostacyclin, thromboxane A2, PGE2 and PGD2 during inflammation (185)

Chang, a traditional Chinese medicinal plant, has the ability to directly bind to the kinase domains of JAK2 and JAK3, effectively inhibiting the JAK/STAT pathway activation

Naltrexone (NTX) relieves inflammation in the collagen-induced- arthritis (CIA) rat models through regulating TLR4/NFB signaling pathway