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The yeast WD40 and WD40 domains are structural homologs with complete conservation of the binding site except for two residues, i.e., His31/Tyr139 in WD40 are replaced by Tyr33/Phe142 in WD40 61,62 (Supplementary Fig

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97 CPI-1612, a potent and selective oral p300 inhibitor, abrogates lactylation and subsequent IL-10 expression in tumor-educated BMDMs without affecting acetylation, thereby countering immunosuppression in GBM

In the mitochondrial inner membrane, flavin adenine dinucleotide (FAD)-dependent choline oxidase catalyzes the conversion of choline to betaine aldehyde, which is then converted to betaine by betaine aldehyde dehydrogenase in either the mitochondrial matrix or the cytosol (2)