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While HMGB1 contributes to the development of hepatic steatosis, it may also lead to the activation of Kupffer cells and the exacerbation of inflammation [227]

Female partners were excluded if they exhibited diminished ovarian reserve, defined as fewer than five oocytes retrieved in a prior IVF cycle or elevated early follicular phase FSH levels, or were aged over 39 years (218). The Cochrane review published in 2019 showed that although the use of AOXs for men prior to IVF did not improve the CPR (OR = 2.64, 95% CI 0.94 to 7.41), the LBR increased significantly (OR = 3.61, 95% CI 1.27)

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Front Oncol 4:64 Pouladvand N, Azarnia M, Zeinali H, Fathi R, Tavana S (2024) An overview of different methods to establish a murine premature ovarian failure model