This reduction contributes to fatigue, sluggish metabolism, and decreased cognitive performance
3 The most common cause of vitamin B12 deficiency is pernicious anaemia, an autoimmune disorder that results in inflammation and damage to the stomach lining
Interleukin-6 (IL-6) regulation is considered to be independent of the aging-related gene P53 and instead is modulated directly by the DNA damage response (DDR), influencing the IL-6 signaling complex expression on cell surfaces (Rodier et al., 2009)
The characteristics include irregular sleepwake rhythm, sleep fragmentation, decreased nocturnal melatonin levels, increased light-induced melatonin suppression, delayed phase of the dim-light melatonin onset (DLMO), and abnormal melatonin synthesis, as reviewed by several authors [10, 50,51,52,53]