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We anticipate that future research aimed at investigating neuropeptide-mediated regulation of mucus secretion and expression will provide new insight into airway pathogenesis, as well as uncover new targets for therapeutic discovery

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Sasaguri H, Nilsson P, Hashimoto S, Nagata K, Saito T, De Strooper B, et al

Moreover, in attempts to replace the hydroxyl group of the tyrosine moiety to avoid potential problems with phase II metabolism compound 27 was prepared ( 27 ) is 10-fold less potent than 25 demonstrating that interactions with the hydroxyl group is important, although not critical for activity