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Natural flavones like quercetin and apigenin act as TrkB agonists, directly binding to the receptors extracellular domain to activate the downstream CREB pathway, thereby reducing apoptosis, oxidative stress, and protein aggregation in cellular models of neurodegeneration (Chiu et al., 2023)

The effects of ketamine on dopaminergic function: meta-analysis and review of the implications for neuropsychiatric disorders

and CAT, APX, and SOD activities and a negative correlation with the contents of GSH

Additionally, visceral adipose tissue releases significant inflammatory and immune mediators (143), stimulating the ovaries and adrenal glands to secrete these hormones (154)