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This regimen has been shown to provide complete blockade of adrenergic neurotransmission for up to 6 h (Pergola et al

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At 2 weeks early stage of the study, edematous changes, severe parenchymal erosion, cellular necrosis, vacuolations, hemorrhagic exudations and severe hemorrhage, distortions in parenchymal tissue architecture, inflammatory and necrotic cells with vacuolations and eosinophilic cells-indicative of cellular degeneration were observed in group B, C and D which shows hepatic alterations Fig