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The procedure is more painful, carries higher risk of nerve or vascular puncture, and often produces post-injection soreness lasting 1224 hours

Measurements used to assess the presence (and in some cases, the strength) of resistance included reports from doctors and their patients experiencing clinical treatment failure ( n = 3), measurements of resistance ratio (RR50 or RR90) based on lethal times ( n = 2), or studies where resistance measures where reported as a resistance factor (RF) ( n = 6), and cell survival rates ( n = 1)

Specifically, after a hypoxic challenge, lobeline locks cells in a stressed state, even after re-exposure to normoxia

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