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used AUC to characterize the solution state of prothymosin , paratymosin , thymosin 1 , and thymosin 4 , resolving early contradictory gel-filtration findings, according to which these proteins appeared as oligomers which were 45 times larger than those calculated from their amino acid sequences (Haritos et al., 1989)

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First in Human Clinical trials (FIH trials) play a critical role in bringing investigational new drugs or interventions to the clinical practice