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The image above shows the two states of GDH bound to NADH: in the open state (left), the outer domains are lifted out away from the core and the multiple catalytic pockets are open, while in the closed state (right), the outer domains are shifted in towards the core of the molecule and the pockets are closed

Structural remodeling is coordinated by regulated gene expression and satellite cell differentiation

These findings suggest BPC-157 may modulate neuroinflammation and promote neural tissue preservation through mechanisms consistent with its known cytoprotective activity in other tissue types

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