These include: Renal impairment impaired kidneys cannot clear excess magnesium and other minerals safely G6PD deficiency high-dose vitamin C can trigger haemolytic anaemia in these patients Congestive heart failure fluid overload risk with IV administration
This pH falls squarely within the overlapping stability window of all three peptides: the copper tripeptide (5.0-7.0), the thymosin fragment (6.0-7.5, though stable from 4.5-7.5), and the body protection compound (6.5-8.5, though stable across wider range)
It will often not happen on the first GSH (it can of course) but if there are methyl cycle slow downs and then yOu supply the B Vit cofactors and a methyl donor suddenly the methyl cycle donates more and more to the HCYS-Cystathionine pathway (which primes sulfite formation and SUOX) and THEN you give GSH which also donates to the same pathway A sulfite reaction can look like anaphylaxis and can have hive reactions and all you mention
At low concentrations, it is a weak inducer of CYP3A4, but at therapeutic levels shows inhibitory properties, suggesting the potential for both auto-induction and inhibition depending on the concentration (Howlader et al., 2022
