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It doesnt mean unregulated

The exploration time in this test was dependent on both the HF diet and MT-II treatment

Identification of the binding domain for NADP+ of human glucose-6-phosphate dehydrogenase by sequence analysis of mutants

It would be a mistake to read this article as saying topical GHK-Cu is definitively proven only that it has more, and more directly relevant, human evidence than the injectable route