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Fujihara, Y., Shauver, M

GPX4 plays a critical role in counteracting ferroptosis by mitigating lipid peroxidation, while other factors like nicotinamide adenine dinucleotide phosphate (NADPH) and coenzyme Q10 (CoQ10) also contribute to ferroptosis regulation ( In addition to these well-characterized mechanisms, recent studies have highlighted alternative ferroptosis surveillance pathways that operate independently of GPX4

Cruzat, V

Moreover, inflammatory mediators, such as Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) and Tumor necrosis factor-alpha (TNF-) increased, while pivotal proteins involved in dendritic and synaptic development, such as Synaptophysin (SYP), postsynaptic density protein 95 (PSD95) and brain-derived neurotrophic factor (BDNF) decreased in APP/PS1 mice