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The gasdermin (GSDM) family includes six members (GSDMA, GSDMB, GSDMC, GSDMD, GSDME and pejvakin), which are primarily expressed in tissues such as the gastrointestinal tract and skin, and serve a key role in regulating pyroptosis (9193)

Its effect likely arises from the modulation of the extracellular matrix and the reduction of oxidative and inflammatory stress at the tissue level [2]

Furthermore, these interactions between these proteins and A, p-tau, and other related factors ultimately influence neuronal function and lead to cognitive deficits, as observed in AD

Researchers have concluded that glutathione deficiency can be a significant factor in several chronic conditions such as (5): Studies also indicate that low glutathione levels may significantly correlate with diseases of the liver, kidneys, lungs, and the digestive system (5)