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This substantial reduction in endogenous Pure Copper peptide production directly correlates with the visible manifestations of skin aging, including decreased elasticity, diminished barrier function, increased transepidermal water loss, and reduced capacity for wound healing and tissue repair

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If the abovementioned is occurring, it could mean that IGF-1 administration could also lower glucose levels by suppressing hepatic gluconeogenesis, as well as improving insulin signalling in this organ, leading to IGFBP-1 suppression and overall improvement of the IGF-1/GH/insulin axis

10.3389/fmed.2019.00265 16 De La VegaF